Inhibition of chymotrypsin-like activity of the proteasome by ixazomib prevents mitochondrial dysfunction during myocardial ischemia.
Toys Other The heart is critically dependent on mitochondrial respiration for energy supply.Ischemia decreases oxygen availability, with catastrophic consequences for cellular energy systems.After a few minutes of ischemia, the mitochondrial respiratory chain halts, ATP levels drop and ion gradients across cell membranes collapse.Activation of cell